Lithographic lecture notes. A tool of forensic medicine teaching. Observation on the lessons of Paolo Pellacani (1884-1885), forensic physician at the University of Pavia.

We focus our attention on the use of lithographed lecture notes written by professors, or more often by students, in the teaching of medicine and surgery courses, between the late 19th and early 20th centuries, a period in which, to better understand the phenomena underlying life and death, collaboration between medical professionals and natural science researchers was intense (1). In particular, we analyzed the lithographed lecture notes of Professor Paolo Pellacani at the University of Pavia for the course of legal medicine.

' to whom it will be extremly Usefull.' Dr William Cullen's adoption of James Watt's copying machine.

Dr William Cullen (1710-1790) was a leading physician of the Enlightenment era. As professor in Edinburgh he became the most influential teacher of theoretical and practical medicine in 18th century Britain. A renowned private practitioner, Cullen systematically archived his postal 'consultations', now held by the Royal College of Physicians of Edinburgh. Initially Cullen preserved his replies as transcriptions, but from April 1781 he began using a mechanical copier, newly devised by the Scottish engineer James Watt. This paper describes the development, promotion and functioning of Watt's copier and considers Cullen's own adoption of the machine. It is suggested that with Cullen's adoption of Watt's copier, medical record keeping entered a new historical phase comparable with the recent digital revolution.

[Ophthalmological reading tests : Part 1: historical aspects]. / Ophthalmologische Leseproben : Teil 1: Historische Aspekte.

BACKGROUND: The objective of this article was an analytical review of reading charts with regard to the historical background, printing techniques, print quality and print size. METHODS: For this study original historical reading charts (Jaeger, Snellen, Nieden and Birkhäuser) were investigated microscopically by measuring the lower case letter sizes (iNexis VMA 2520, Nikon, Tokyo). Calculations were made according to EN ISO 8596 and the recommendations of the International Research Council. RESULTS: In the mid-nineteenth century various reading cards were published; however, at that time it was not possible to print lower case letters according to exactly defined standards. Thus, these reading cards were not comparable to each other or between different language versions. At a reading distance of 32 cm Jaeger No. 1 represented in the original edition (1856) a visual acuity of 0.72 and 0.63 in the version from 1945 and the smallest print size of the Snellen reading test (1862) represented 0.55. Nieden No. 1 (1882) corresponded to a visual acuity of 0.59 and the smallest print size of the Birkhäuser cards (1911) 1.5. In the case of all reading cards except the original Birkhäuser cards, there was no logarithmic progression of the print sizes and the sizes of numbers were also not in accordance with the corresponding letter sizes. CONCLUSION: Print sizes of historical reading charts do not adhere to current standards and were usually not logarithmically scaled. These deficits and the lack of comparability between the historical reading charts may have caused reading cards to be currently underestimated as an accurate diagnostic tool. Nevertheless, the historical reading charts were the successful forerunners of developments for modern reading charts.

[Textual research on the engraved editions of Nei wai yan fang mi chuan (Secret Teaching of Proved Prescriptions for Internal and External Diseases)].

Zhao Lian's book Nei wai yan fang mi chuan (Secret Teaching of Proved Prescriptions for Internal and External Diseases) was firstly engraved in the 21st year of Guangxu reign of the Qing dynasty. There are altogether four different engraved editions separately collected in the Library of Academy of Medical Sciences, Library of Zhenjiang City, Library of Changchun University of TCM, and Library of Shanghai University of TCM, printed in different times with different sizes of its contents. It is better to call all these editions the engraved versions of Guangxu reign. All of them are engraved and printed after the mother edition with some blocks hollowed-out and supplemented. Hence, the title "engraved edition of Yiyou or the 11th year of Guangxu reign (1885) of the Qing dynasty" carried in The General Catalogue of Ancient Books of TCM is wrong.

The dawn of the third renaissance in surgery.

In this presidential address, I will share my belief that our proud and noble field stands at the dawn of a great renaissance. I further believe that this is the third such renaissance that has occurred in surgery. As described herein, the first renaissance in surgery occurred during the 1600s, which involved a transformation in operative care unlike anything that had been seen since Roman times. This first renaissance was triggered by tumultuous world events but was spurred on by the invention of the printing press. The second renaissance occurred during the 1980s and was triggered by the invention of the computer, which is of equal significance to the printing press 240 years earlier. I believe that this third renaissance shares with the earlier renaissances its transformative nature and its reaction to turmoil, both in the medical and nonmedical worlds. This is a renaissance driven by science, by creativity, and by innovation­resources that are never in short supply within our great profession.

Galen, father of systematic medicine. An essay on the evolution of modern medicine and cardiology.

Galen (129-217) was the ultimate authority on all medical subjects for 15 centuries. His anatomical/physiological concepts remained unchallenged until well into the 17th century. He wrote over 600 treatises, of which less than one-third exist today. The Galenic corpus is stupendous in magnitude; the index of word-entries in it contains 1300 pages. Galen's errors attracted later attention, but we should balance the merits and faults in his work because both exerted profound influences on the advancement of medicine and cardiology. Galen admonished us to embrace truth as identified by experiment, warning that everyone's writings must be corroborated by directly interrogating Nature. His experimental methods' mastery is demonstrated in his researches, spanning every specialty. In his life-sustaining schema, the venous, arterial, and nervous systems, with the liver, heart, and brain as their respective centers, were separate, each distributing through the body one of three pneumata: respectively, the natural, the vital, and the animal spirits. He saw blood carried both within the venous and arterial systems, which communicated by invisible "anastomoses," but circulation eluded him. The "divine Galen's" writings, however, contributed to Harvey's singular ability to see mechanisms completely differently than other researchers, thinkers and experimentalists. Galen was the first physician to use the pulse as a sign of illness. Some representative study areas included embryology, neurology, myology, respiration, reproductive medicine, and urology. He improved the science and use of drugs in therapeutics. Besides his astounding reputation as scientist-author and philosopher, Galen was deemed a highly ethical clinician and brilliant diagnostician.

[Panfilo Castaldi (1430? - 1487): a physician-typographer]. / Panfilo Castaldi (1430? - 1487): il medico-tipografo.

The issue about whether it was Johann Gutenberg in Mainz or Panfilo Castaldi in Feltre (in the Italian region of Veneto) to first invent movable metal type for printing around 1450 still raises a controversy, even though Gutenberg is generally perceived as the one. What is beyond doubt, however, is that Castaldi pioneered the new revolutionary printing method with the historical texts written by great physicians such as Hippocrates, Galen, and Avicenna. His early publishing success raised bitter competition all around him, which eventually drove him out of this flourishing business, and he returned to his long-neglected medical profession. Castaldi's new "art" was received coldly by his apprehensive fellow citizens. As soon as he was buried, they invaded the printing office and, believing that the printing machines were the "devil's instruments", tore it apart.

An analysis of historical exposures of pressmen to airborne benzene (1938-2006).

Benzene is an aromatic hydrocarbon that, with sufficient cumulative lifetime doses, can cause acute myelogenous leukemia. Because of its volatility and solvent properties, it was used in the printing industry in inks, ink solvents, and cleaning agents from the 1930s to the 1970s. This analysis represents the first known attempt to gather and synthesize the available data on historical airborne benzene concentrations in printing facilities and exposures to pressmen. The sources of fugitive benzene vapors from printing operations have been identified as evaporation from ink fountains, exposed sections of the printing cylinder, the paper web, the paper post exit, and spilled ink. In addition, specific activities that could lead to benzene exposure, such as filling the fountains, using solvents to clean the press, and using solvents as personal cleaning agents, potentially occurred multiple times per work period. Eighteen studies were identified that reported workplace airborne concentrations in printing facilities between 1938 and 2006. Typical benzene air concentrations, considering both personal and area samples of various durations, were as high as 200 p.p.m. in the 1930s through the 1950s, 3-35 p.p.m. in the 1960s, 1.3-16 p.p.m. in the 1970s, 0.013-1 in the 1980s, and far less than 1 p.p.m. in the 1990s and 2000s. The decrease in benzene air concentrations by the late 1970s was likely to be linked to the decreased benzene content of printing materials, increased engineering controls, and to more stringent occupational exposure limits.

The Physician as Printer/Publisher: a Rare, but not Unsurprising Combination.

Progress in medicine and science has depended much upon the production and circulation of written material. While, throughout history, medical doctors have been actively involved in a wide variety of other fields, such as philosophy, poetry, literature, sciences, politics and the military, many of which have led to the writing of material - it seems that only rarely have physicians become printers and/or publishers. In general those becoming physicians have been characterised as studious, curious, thoughtful, pragmatic, largely even-tempered, dutiful, caring and compassionate.Yet, the reasons why an established physician might take time away from his medical duties to enter the arena of printing and publishing arena are unclear.

The role of images in the development of Renaissance natural history.

This review surveys recent scholarship on the history of natural history with special attention to the role of images in the Renaissance. It discusses how classicism, collecting and printing were important catalysts for the Renaissance study of nature. Classicism provided inspiration of how to study and what kind of object to examine in nature, and several images from the period can be shown to reflect these classical values. The development of the passion for collecting and the rise of commerce in nature's commodities led to the circulation of a large number of exotic flora and fauna. Pictures enabled scholars to access unobtainable objects, build up knowledge of rare objects over time, and study them long after the live specimens had died away. Printing replicated pictures alongside texts and enabled scholars to share and accumulate knowledge. Images, alongside objects and text, were an important means of studying nature. Naturalists' images, in turn, became part of a larger visual culture in which nature was regarded as a beautiful and fascinating object of admiration.

[Johann Misch Astrophilus' book "Medicina Pauperum" in Hungarian. Copy of a lost or hidden book from 1660]. / Johann Misch Astrophilus "Szegények patikája" muve magyarul. Egy elveszett vagy lappangó könyv másolt, teljes kézirata 1660-ból.

Doctors and pharmacies in the 15th Century only used handwritten copies of the prescription collections available in their time. At the beginning of book printing the publishing of prescription collections immediately became popular. They could be found on the pages of medical and pharmaceutical books of many various editions with different structure and origin, as the forerunner of the official pharmacopoeias. From the 16th Century onwards books with the title "Medicina Pauperum" were published which helped the educated people to tend to themselves, the household, the servants and their immediate surroundings case of an illness. The first work specifically on the topic or of genre of the "Medicina Pauperum" according to our knowledge appeared in Hungarian in the year 1660 and currently seems to survived only in fragments under the title of "Medicina Pauperum", from an unknown author. A rare incident occurred in the present days as a "book" believed to be lost for us turned up from thin air. It is a "copied" manuscript in the size of 97×139 mm attached to the ribs with hemp cord, cropped around and in an unbound state. The book known before only in fractions is now available entirety handwritten on 318 pages, distributed to seven distinct parts. The research of its origin suggests that the author lived and worked in Nagyszombat and was called Johann Misch Astrophilus. The identification of the printing office was possible thanks to the examination of the initials and the gaudily, as well as the fonts and the watermark. By these results the printing very likely occurred in the Brewer Printing Press in Locse. For the possibility of more extensive research and value preservation the manuscript was bounded. The facsimile edition contains the magnified and digitalized pages of the original one and is published in numbered issues.

Marginalia, commonplaces, and correspondence: scribal exchange in early modern science.

In recent years, historians of science have increasingly turned their attention to the "print culture" of early modern science. These studies have revealed that printing, as both a technology and a social and economic system, structured the forms and meanings of natural knowledge. Yet in early modern Europe, naturalists, including John Aubrey, John Evelyn, and John Ray, whose work is discussed in this paper, often shared and read scientific texts in manuscript either before or in lieu of printing. Scribal exchange, exemplified in the circulation of writings like commonplace books, marginalia, manuscript treatises, and correspondence, was the primary means by which communities of naturalists constructed scientific knowledge. Print and manuscript were necessary partners. Manuscript fostered close collaboration, and could be circulated relatively cheaply; but, unlike print, it could not reliably secure priority or survival for posterity. Naturalists approached scribal and print communication strategically, choosing the medium that best suited their goals at any given moment. As a result, print and scribal modes of disseminating information, constructing natural knowledge, and organizing communities developed in tandem. Practices typically associated with print culture manifested themselves in scribal texts and exchanges, and vice versa. "Print culture" cannot be hived off from "scribal culture." Rather, in their daily jottings and exchanges, naturalists inhabited, and produced, one common culture of communication.